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Arachidonate 5-lipoxygenase inhibitor : ウィキペディア英語版 | Arachidonate 5-lipoxygenase inhibitor Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma and allergic rhinitis.〔David L. Nelson, Michael M. Cox. ''Lehninger's Principles of Biochemistry, Fifth Edition''. W.H. Freeman and Co., 2008, p. 359.〕 Examples of 5-LOX inhibitors include drugs, such as meclofenamate sodium〔 and zileuton.〔 Some chemicals found in trace amounts in food, and some dietary supplements, also have been shown in inhibit 5-LOX, such as baicalein, caffeic acid,〔 curcumin,〔 hyperforin〔〔〔 and St John's wort. ==See also==
*Antileukotriene agents
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